中国畜牧兽医2012，Vol.39Issue(1)：97-100,4.
朊蛋白与金属离子之间作用的研究进展
Advance in Relationship between PrP and Metal Ions
摘要
Abstract
PrPsc is the misfording of the normal cellular form of the prion protein (PrPc ), They are coincidence between Amino Acid sequence, PrPSc has a high β-sheet content, while PrP is abundant on or helical structure. Scientists have not study the function clearly. During the process of people and animal infect with or get PrP, Most scientists think some important cofactors influence pathological change such as the structure change of PrP, spread of PrPsc, and PrPsc leads to the dead of nerve cell, so researching of this cofactors will help us to explain this questions, this cofactors consisit of many metal ions, such as Ca2+ ,Fe2+ ,Cu2+ ,Mn2+. We discribe the influence of metal ion on PrP struction and function, and they may be effect on the pathogenesy of TSEs.关键词
朊病毒病/Ca2+/Fe2+/Cu2+/Zn2+/Mn2+Key words
prion disease/ Ca2+ / Fe2+ /Cu2+ /Zn2+ /Mn2+分类
农业科技引用本文复制引用
张晓晶,刘林娜,刘晋平,钱军,鞠传静,万家余,孟轲音,李忠义,郝镯,汤鑫,王东旭,刘文森..朊蛋白与金属离子之间作用的研究进展[J].中国畜牧兽医,2012,39(1):97-100,4.基金项目
国家自然基金资助项目(30972197,31072148) （30972197,31072148）
吉林省科技发展计划项目(201105038). （201105038）
