中国畜牧兽医2012，Vol.39Issue(2)：101-105,5.
去乙酰化酶SIRT1及其对细胞凋亡调控的研究进展
Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation
摘要
Abstract
Apoptosis plays an important role in physiological functions in organisms. It's an essential way to get rid of damaged, senescent, potentially harmful cells in organisms. Silent information regulator 2 homolog KSIRT1) is a member of the mammalian sirtuins, which is widly researched as an important regulatory factor ever since discoveried. Recent studies indicate that SIRT1 targets a wide range of transcriptional regulators including protein 53 (p53) ,forkhead box class O (FOXO) proteins and nuclear factor-κB (NF-kB) , which suggests SIRT1 may has capital effects in apoptosis. This review introduced the molecular biology feature of SIRT1, expression regulation and the relationship between SIRT1 and apoptosis.关键词
细胞凋亡/SIRT1/表达调控Key words
apoptosis/SIRT1/expression regulation分类
生物科学引用本文复制引用
赵芳,李碧侠,任守文,刘红林,王学敏,方晓敏..去乙酰化酶SIRT1及其对细胞凋亡调控的研究进展[J].中国畜牧兽医,2012,39(2):101-105,5.基金项目
江苏省自然科学基金(BK2010466) （BK2010466）
江苏省农业科技自主创新资金(CX(10)422) （CX(10）
国家生猪现代产业技术体系南京综合试验站(nycytx-009) （nycytx-009）
转基因生物新品种培育重大专项(2009ZX08009-1 53B). （2009ZX08009-1 53B）
