中国畜牧兽医2012，Vol.39Issue(3)：220-223,4.
对乙酰氨基酚琥珀酸酯的合成及其表征分析
Study on the Synthesis of Paracetamol Succinate and its Characteristics
摘要
Abstract
Paracetamol succinate( AP-S) was synthesized from paracetamol and succinic anhydride by using 4-dimethylamin-opyridine (DMAP) as catalyst and acetone as solvent. AP-S yield was selected as the main index, the synthetic technology was optimized by an orthogonal design including factors such as raw material monomer ratio, solvent dosage, reaction temperature, reaction time and so on. Characteristics of AP-S were identified by chemical identification, Ph test, melting point test, IR, UV and HPLC. In result, the features of resultants was consistant with AP-S. The optimized synthetic technology was succinic anhydride and paracetamol monomer ratio 2:1, catalyst 0. 15 g, acetone 30 Ml, temperature 60 °C and time 6 h, and the yield was 81. 7%.关键词
对乙酰氨基酚琥珀酸酯/4-二甲氨基吡啶/合成工艺/表征Key words
paracetamol succinate/DMAP/synthesis technology/characteristics分类
医药卫生引用本文复制引用
金超,靳晓优,唐文,周涛,符华林..对乙酰氨基酚琥珀酸酯的合成及其表征分析[J].中国畜牧兽医,2012,39(3):220-223,4.基金项目
四川农业大学国家级大学生创新性实验计划资助 （）
教育部“长江学者和创新团队发展计划”创新团队项目(IRT0848). （IRT0848）
