中国药房2012，Vol.23Issue(10)：890-893,4.DOI:10.6039/j.issn.1001-0408.2012.10.10
38株多重耐药鲍曼不动杆菌超广谱酶基因的研究
Study on Extended-spectrum β-lactamase Genes in 38 Strains of Multidrug Resistant Acinetobacter Baumannii
摘要
Abstract
OBJECTIVE: To investigate the existence of extended spectrum β-lactamase genes in 38 strains of multidrug resis-tant Acinetobacter baumannii in the First Affiliated Hostpital of Liaoning Medical University. METHODS: Trace dilution method was used to detect the drug resistance of 38 strains of multidrug resistant A. baumannii against 14 kinds of antimicrobial agents. The extended spectrum β-lactamase genes were detected by using PCR assay and gene sequencing. RESULTS: It was found that 38 strains of multidrug resistant A. baumannii isolated were resistant to 14 different antimicrobial drugs. To the extended spectrum β-lac-tamase genes tested, the positive strains with TEM, PER-1 and SHV were 33 (86.84% ), 5(13.16% ), 1 (2.63% ), respectively. Among these strains, 5 strains were positive with both TEM and PER-1, 1 strain positive with both TEM and SHV. CTX, GES and VEB genes were not found in all isolates. CONCLUSION: The extended spectrum /Mactamase genes are varied in A. baumannii from our hospital. Antimicrobial agents should be used rationally to decrease multi-drug resistance.关键词
鲍曼不动杆菌/多重耐药/超广谱酶/基因Key words
Acinetobacter baumannii/ Multidrug resistance/ Extended spectrum β-lactamase/ Gene分类
医药卫生引用本文复制引用
郭雷静,李鑫,张淑芹,陆思静..38株多重耐药鲍曼不动杆菌超广谱酶基因的研究[J].中国药房,2012,23(10):890-893,4.基金项目
辽宁省教育厅基金(2008402) （2008402）
辽宁省科技厅基金(200922501041) （200922501041）
