中国药房2012，Vol.23Issue(10)：905-907,3.DOI:10.6039/j.issn.1001-0408.2012.10.16
我院2009-2010年抗菌药物使用与细菌耐药性分析
Utilization of Antibacterial Agents and Analysis of Drug Resistance in Our Hospital during 2009-2010
董懿珍1
作者信息
- 1. 开封市儿童医院药研室,河南开封475000
- 折叠
摘要
Abstract
OBJECTIVE: To realize the change of the drug resistance and the application of antibacterial agents in recent 2 years, to discuss the relativity of the amount of antibacterial agents and the change of drug resistance in our hospital, and to guide the rational drug use in the clinic. METHODS: We collected the distribution, constitution and drug resistance of the pathogenic bac-teria which were isolated and cultivated from the clinical samples and the DDDs of the commonly used antibacterial agents in the clinic from 2009 to 2010 were analyzed retrospectively and comparatively. RESULTS: We isolated 1977 strains of pathogenic bacte-ria for two years. Gram-negative bacilli was 67.98% of all; Gram-positive coccus was 31.21% of all; the fung was 0.81% of all. Top 5 pathogenic bacteria were Escherichia coli, Staphylococcus epidermidis, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. DDDs of 12 kinds of antibacterial agents increased among the top 20 ones, especially the DDDs of cefox-itin and ceftazidime; the separation of the multiple drug-resistant strains and the drug resistance rate ascended in varying degrees year by year. CONCLUSION: With the large amount of the third generation cephalosporin and the cephamycins used, the drug re-sistance rate of bacteria is increasing yearly in our hospital. We need enhance the management of the clinical antibacterial drugs in grading application and monitoring of drug resistance.关键词
病原菌/抗菌药物/耐药性/药敏分析/用药频度/用药管理Key words
Pathogenic bacteria/ Antibacterial agents/ Drug resistance/ Drug sensitivity analysis/ DDDs/ Management of drug use分类
医药卫生引用本文复制引用
董懿珍..我院2009-2010年抗菌药物使用与细菌耐药性分析[J].中国药房,2012,23(10):905-907,3.
