中国药房2012，Vol.23Issue(10)：912-914,3.DOI:10.6039/j.issn.1001-0408.2012.10.19
高流量氧气驱动布地奈德混悬液雾化吸入治疗AECOPD并Ⅱ型呼吸衰竭的安全性研究
Safety Study on High Flow Oxygen-driven Aerosol Inhalation of Budesonide Suspension for AECOPD Complicating with Type Ⅱ Respiratory Failure
摘要
Abstract
OBJECTIVE: To study the safety of high flow oxygen-driven aerosol inhalation (HFODAI) of Budesonide suspen-sion for AECOPD complicating with type II respiratory failure. METHODS: 139 AECOPD patients with type II respiratory failure were randomized into treatment group (Budesonide suspension) and control group (Budesonide suspension+Salbutamol sulfate aero-sol solution). All the treatments between two groups were the same except HFODAI. The immediate change of blood gases and heart rates was recorded before and after HFODAI at the first day. RESULTS: In treatment group, PaO2 was (50.8 ±6.11) mmHg and (79.6 ± 7.03) mmHg,t=3.41,P<0.05; and PaCO2 was (68.3 ± 5.46) mmHg and (71.3 ± 6.56) mmHg,t=1.51,P>0.05 be-fore and after HFODAI; the heart rate was (112.6 ± 10.23) b·min-1, (105.719.68) b-mun-1,t=1.01,P>0.05 before and after HFODAI. In control group, PaO2 was (51.6 ± 5.98) mmHg and (80.1 ± 6.67) mmHg,r=3.53,P<0.05 before and after HFODAI; and PaCO2 was (67.8 ± 6.71) mmHg and (50.1 ± 5.73) mmHg, t= 2.98, P<0.05 before and after HFODAI; the heart rate was (115.4±9.87) b·min-1 and (126.9± 11.48) b·min-1,t=1.09,P>0.05 before and after HFODAI. The difference of the heart rates after HFODAI in two groups was significant (t=1.97,P<0.05) . CONCLUSION: HFODAI of Budesonide suspension for AECO-PD complicating with type Ⅱ respiratory failure is safe and effective, but Budesonide suspension alone may have the trend to in-crease PaCO2. Oxygen-driven aerosol inhalation of Budesonide suspension combined with Salbutamol sulfate solution can improve hypercapnia in AECOPD patients with type Ⅱ respiratory failure but enhance heart rate.关键词
高流量氧气驱动雾化吸入/布地奈德混悬液/慢性阻塞性肺疾病急性加重期/Ⅱ型呼吸衰竭/安全性Key words
High flow oxygen-driven aerosol inhalation/ Budesonide suspension/ AECOPD/ Type II respiratory failure/ Safe-ty分类
医药卫生引用本文复制引用
叶勉之,陈磊,翁磊,王岑立,周蕾,施春娜,潘丽萍,柳春波,邓在春..高流量氧气驱动布地奈德混悬液雾化吸入治疗AECOPD并Ⅱ型呼吸衰竭的安全性研究[J].中国药房,2012,23(10):912-914,3.基金项目
宁波大学2011年度校级科研项目(XYY11055) （XYY11055）
