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不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量

刘海涛 王俊秋 余立

中国药业2012,Vol.21Issue(7):15-16,2.
中国药业2012,Vol.21Issue(7):15-16,2.

不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量

Evaluation of Quality of Propranolol Hydrochloride Tablets by Dissolution Curves in Different Mediums

刘海涛 1王俊秋 1余立1

作者信息

  • 1. 北京市药品检验所,北京,100032
  • 折叠

摘要

Abstract

Objective To detect the dissolution of propranolol hydrochloride tablets from different pharmaceutical factories in 4 different mediums and evaluate the quality by dissolution curves. Methods The dissolution test was carried out with paddle - rotating method. To analyse and compare the results by the dissolution curves in different mediums. Results and Conclusion There was significant difference in dissolution parameters and the quality among the propranolol hydrochloride tablets preparations from different manufactories.

关键词

盐酸普萘洛尔片/溶出度/溶出曲线/紫外分光光度法

Key words

Propranolol Hydrochloride Tablets/dissolution/Weibull Equation/UV - spectrophotometry

分类

医药卫生

引用本文复制引用

刘海涛,王俊秋,余立..不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量[J].中国药业,2012,21(7):15-16,2.

中国药业

OACSTPCD

1006-4931

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