摘要
Abstract
Objective To comparatively observe the curative effects of docetaxel, epirubicin and cyclophosphamide (TEC) regimen and cyclophosphamide, epirubicin and fluorouracil(CEF) regimen in the treatment of breast cancer. Methods Three hundred and eighty patients with breast cancer in our hospital from April 2003 to June 2010 were divided into two groups, the TEC group(rt=85) and the CEF group ( n = 295), and treated by TEC and CEF regimens respectively. The efficacy and toxicity were evaluated in the two groups. Results The total effective rate was 87. 06% in the TEC group and 53. 90% in the CEF group with statistical difference between them (P<0.05).The occurrence rate of neutropenia was 91.86% in the TEC group and significantly higher than 76.61% in the CEF group, showing statistical difference between the two groups (P<0.05).The major adverse reactions of two groups were nausea, vomiting, hair loss, anemia, neutropenia, cardiac toxicity and abnormal liver function. Conclusion The adverse reactions of two regimens are mild and tolerable. The TEC regimen has better effects, which can be used as the routine drugs of neoadjuvant chemotherapy.关键词
多西紫杉醇/表阿霉素/环磷酰胺/化学治疗/乳腺癌Key words
TEC/CEF/cyclophosphamide/chemotherapy/breast cancer分类
医药卫生
