中国中西医结合影像学杂志2012，Vol.10Issue(1)：4-9,封2,7.DOI:10.3969/j.issn.1672-0512.2012.01.002
针刺太冲穴得气及疼痛激发相对抗的脑功能网络效应fMRI研究
Deqi and Sharp pain during acupuncture at Taichong eliciting the opposite functional brain network effects--an fMRI study
摘要
Abstract
Objective: To investigate the needling sensations (deqi and sharp pain)coupling with fMRI signal change in the brain functional network upon acupuncture at Taichong (LV3). Methods:Forty seven acupuncture-nave normal subjects received manual acupuncture at Taichong(LV3 ,right)during fMRI scan ,and 17 of them received superficial tactile stimulation at LV 3 prior to acupuncture procedures as control. Right after acupuncture or tactile stimulation procedures ,all subjects were interviewed by our researchers with a sensation questionnaire. The collected data were then divided into the following three groups :1)acupunc-ture deqi. 2)acupuncture pain :acupuncture deqi mixed with sharp pain. 3)sensory control :tactile stimulation. Results :The deqi sensations such as aching ,soreness ,pressure,numbness and dull pain experienced by the subjects were significantly more frequent and the intensity ratings were significantly higher in acupuncture than in sensory control. Activation of the somatosensory cortex was observed in all groups , but significantly more marked in subjects who experienced sharp pain during acupuncture. Importantly ,the majority of the cohort who experienced deqi without sharp pain demonstrated prominent signal de -creases in the limbic-paralimbic-neocortical network (LPNN)widely spread across the brain including the amygdala,hippocampus ,parahippocampus ,temporal pole ,pregenual and subgenual cingulate ,ventromedial prefrontal cortex ,precuneus and posterior cingulate(BA31,23_ventral ,29 ,30) ,cerebellar vermis ,the periaqueductal gray and reticular formation in the brainstem. A large subset of these regions is involved in the affective and cognitive dimensions of pain.The decreases of the signal intensity in these areas were significantly attenuated or changed to signal increases with the development of sharp pain in acupuncture . Major regions in the LPNN were found overlapped with the Default mode network in the resting Brain .Conclusions : The findings provide support for the hypothesis that acupuncture modulates the limbic-paralimbic-neocortical network and pain neu-romatrix activity to produce its anti-pain,anti-stress and other modulatory effects. The similarity of LPNN and default mode network in the resting brain suggests that acupuncture may mobilize the important brain intrinsic network for its multiple mod -ulation effects.关键词
针刺感应/疼痛/神经网/磁共振成像/针刺镇痛Key words
Needling sensation response /pain /nerve net /magnetic resonance imaging /acupuncture analgesia分类
医药卫生引用本文复制引用
方继良,Hui KS Kathleen,Liu Jing,Nixon Erika,周科华,王小玲,朱兵..针刺太冲穴得气及疼痛激发相对抗的脑功能网络效应fMRI研究[J].中国中西医结合影像学杂志,2012,10(1):4-9,封2,7.基金项目
美国国立卫生研究院替代医学中心(编号:7F05AT003022-03,04) （编号:7F05AT003022-03,04）
国家自然基金面上课题(编号:30870668) （编号:30870668）
国家重点基础研究发展计划(973计划)(编号:2011CB505200). （973计划）
