中国卒中杂志2012，Vol.7Issue(2)：86-90,5.
染色体9p21上rs2383206单核苷酸多态性与中国汉族脑梗死的相关性分析
Association of Rs2383206 Single Nucleotide Polymorphism on Chromosome 9p21 and Cerebral Infarction in Chinese Han
李淑娟 1张玉杰 2刘东涛 1陈冬辉 2王笑峰 3胡文立1
作者信息
- 1. 100020北京,首都医科大学附属北京朝阳医院神经内科
- 2. 满洲里市第一医院神经内科
- 3. 复旦大学生命科学学院遗传学研究所
- 折叠
摘要
Abstract
Objective To investigate the association of rs23 83206 single nucleotide polymorphism(SNP) on chromosome 9p21 and cerebral infarction in northern Chinese Han population. >Methods Three hundred and fifty-five cases of patients with early cerebral infarction(CI grpup) and 430 cases of surgical patients hospitalized over the same period as controls. PCR-SNP Stream technology was used to genotype rs23 83206 polymorphism, and genotyping results were statistically analyzed.Results The frequency of genotype AG of rs2383206 was increased in CI group, compared with control group, P=0.007). G allele frequency of rs2383206 was also higher in CI group than control group. After adjusting for confounding factors, we found that, compared yith AA homozygotes of the rs2383206, GG/GA genotype has significant effect to increase the risk of cerebral infarction(adjusted OR 1.23, 95%CI 1.11-2.05, P=0.009). rs2383206 G-allele increased the risk of large artery atherosclerotic stroke by 2.09 times. Conclusion Rs2383206 is the susceptible locus to CI in Chinese Hans.关键词
遗传/多态性/单核苷酸/脑梗死Key words
Genetics/ Polymorphism, single nucleotide/ Infarction引用本文复制引用
李淑娟,张玉杰,刘东涛,陈冬辉,王笑峰,胡文立..染色体9p21上rs2383206单核苷酸多态性与中国汉族脑梗死的相关性分析[J].中国卒中杂志,2012,7(2):86-90,5.
