摘要
Abstract
Objective To study the curative effect and safety of dl-3-budylphthalinde and cinepazidemaleateon acute cerebral infarction.Methods One hundred and sixty patients with acute cerebral infarction were divided intofour groups continuously and randomlyxombination therapy group(40cases), budylphthalindegroup(40cases), dl-3-budylphthalinde group(40cases) and conventional treatment group(40cases).Neural function defect and activity of daily living were tested by National Institutes of HealthStroke Scale(NIHSS) and Barthel Index(BI) before therapy and after two weeks and six monthtreatment. Adverse events were statistically analyzed.Results NIHSS total score after two weeks treatment, Compared with conventionaltreatment group, budylphthalinde group or dl-3-budylphthalinde used alone has no statisticalsignificance(P>0.05), but there was synergy between the two drugs(P<0.01). BI after two weekstreatment, budylphthalinde group or dl-3-budylphthalinde used alone has statistical significance(P=0.029, ,P=0.002), but combination therapy group has better effect(P=0.001). NIHSS total scoreand BI after six month treatment, budylphthalinde group or dl-3-budylphthalinde used aloneor combination therapy has significant curative effect(P<0.01), and combination therapy grouphas better effect. The 1 case in therapy group, 2 cases in dl-3-budylphthalinde group, 1 case inconventional treatment group appeared upset stomach. Symptoms improved after symptomatictreatment.Conclusion There was synergy between 1-3-budylphthalinde combined with cinepazidemaleate. It is an effective and safe method to treat acute cerebral infarction by the two drugs.关键词
丁苯酞/马来酸桂哌齐特/脑梗死/治疗Key words
Dl-3-budylphthalinde/ Cinepazidemaleate/ Brain infarction/ Treatment
