中华临床免疫和变态反应杂志2012，Vol.6Issue(1)：34-37,4.
系统性硬化症合并甲状腺功能减退患者的临床分析
Clinical Analysis of Systemic Sclerosis Patients with Hypothyroidism
摘要
Abstract
Objective To investigate the prevalence and clinical characteristics of systemic sclerosis ( SSc ) patients with hypothyroidism. Methods Medical charts of 14 consecutive SSc patients adimitted to Peking Union Medical College Hospital ( PUMCH ) from Jan. 2002 to Sep. 2010 were systematically reviewed. Ninety-two SSc patients without hypothyroidism from Chinese EUSTAR Database between Feb. 2009 and Nov. 2009 were selected as controls. Results There were 344 SSc patients admitted in PUMCH from Jan. 2002 to Sep. 2010. 20 patients ( 6. 1% ) had thyroid diseases, 14 cases had hypothyroidism. All patients were female. According to univariate analysis, there were significant differences in pericardial effusion ( 50% vs. 16.3% , P = 0.012 ), increased ESR ( 64.3% vs. 27. 2% , P = 0. 011 ) and anti-Sc1-70 antibody positivity ( 21. 4% vs. 46. 7% , P = 0. 018 ) between patients with and without hypothyroidism. Conclusion Hypothyroidism ( including subclinical hypothyroidism ) is the most common thyroid disease in SSc patients, especially in that with pericardialeffusion, increased ESR, and anti-Sc1-70 antibody negative.关键词
系统性硬化症/甲状腺功能减退Key words
systemic sclerosis/hypothyroidism分类
医药卫生引用本文复制引用
张雪,赵丽丹,徐东,曾小峰,张奉春..系统性硬化症合并甲状腺功能减退患者的临床分析[J].中华临床免疫和变态反应杂志,2012,6(1):34-37,4.基金项目
欧洲抗风湿病联盟硬皮病试验研究组(EULAR Scleroderma Trial and Research group,EUSTAR),国家自然科学基金(81072485),首都医学发展科研基金重点支持项目(2009-2003),中华医学会临床医学科研专项资金项目(08010270105) （EULAR Scleroderma Trial and Research group,EUSTAR）
