浙江医学2012，Vol.34Issue(5)：317-319,3.
立体定向放射外科治疗脑膜瘤的研究
Stereotactic radiosurgery in treatment of intracranial meningiomas
黄礼明 1朱飚 1卢刚 1厉民 2赵仲生 3王坚2
作者信息
- 1. 310014,杭州,浙江省人民医院神经外科
- 2. 310014,杭州,浙江省人民医院立体定向放射外科治疗中心
- 3. 310014,杭州,浙江省人民医院病理科
- 折叠
摘要
Abstract
Objective To investigate the efficacy of stereotactic radiosurgery in treatment of intracranial meningiomas andits strategies.Methods MethodsTotal 428 patients with intracranial meningiomas were enrolled in the study. Among them 167 caseswere diagnosed by clinical images and another 261 were confirmed by histology; 82 tumors were located on the protruding surface, 211 on the base skull, 23 were intraventricular meningiomas and 112 in other locatins. All patients were treated with stereotactic radiosurgery; a median margin dose of 13.5 Gy and a median central dose of 26.3 Gy were delivered with dose-curve of 40~50%. The therapeutic effects were evaluated by imaging and histological investigation 2y after radiosurgery. Among 428 cases, tumors were reduced in 57 (13.3%), no change in 297 (69.4%) and progress in 6 (1.4%). Sixty eight (15.9%) patients had serious complications with refractory peritumoral vasogenic brain edema and radiated-encephalon. Forty three cases underwent angiography examinations and the diluted tumorous vascular stain was observed in 37. Fifty nine patients received surgery after stereotactic radiosurgery, and main histological demonstrated the decreased proliferating-index of tumor cells; thrombosis, embolism and interstitial hyperplasia.results ConclusionsStereotactic radiosurgery can inhibit tumor cell proliferation,reduce blood-supplying of tumor and might be used as additional minimally invasive management option for intracranial meningiomas in patients who either fail or are unsuitable for resection.关键词
脑膜瘤/立体定向放射外科/放射生物学效应/疗效Key words
Meningioma/Stereotactic radiosurgery/Radio-biological effect Therapeutic effects引用本文复制引用
黄礼明,朱飚,卢刚,厉民,赵仲生,王坚..立体定向放射外科治疗脑膜瘤的研究[J].浙江医学,2012,34(5):317-319,3.
