浙江医学2012，Vol.34Issue(6)：417-419,421,4.
散发性胆囊癌hMLH1和hMSH2蛋白表达检测及其临床意义
Expression and clinical significance of hMLH1 and hMSH2 proteins in patients with sporadic gallbladder carcinoma
张国强 1王晔恺 1周吉航 1卢海英2
作者信息
- 1. 316004,舟山医院普外科
- 2. 浙江海洋学院医学院
- 折叠
摘要
Abstract
Objective This study is to determinate the expressions of mismatch repair proteins human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2) in patients with sporadic gallbladder carcinoma and investigate the relationships between hMLH1,hMSH2 and the tumor occurrence and metastasis. Methods 47 patients with sporadic gallbladder carcinoma from January 2003 to January 2006 were selected and the expressions of hMLH1 and hMSH2 proteins in carcinoma tissue were detected by Envision immunohistochemical techniques. Results The positive rates of hMLH1 and hMSH2 proteins in patients with sporadic gallbladder carcinoma were 51.06% (24/47) and 42.55% (20/47). The positive rate of hMLH1 in liver invasion negative group (19/29,65.51%) was significant higher than liver invasion positive group (5/18,27.78%)(x2=6.33,P<;0.05);the positive rate of hMLH1 in lymph node metastasis negative group (19/27,70.37%) was significant higher than liver invasion positive group (5/20,25.00%)(x2=9.46,P<0.01); the positive rate of hMLH1 in nevin l+ II + III stages group (17/23,73.91%) was significant higher than IV+V stages group(7/24,29.17%)( x2=9.41 ,P<0.01). Conclusion The expression of hMLH1 protein is closely associated with progenesis and metastasis of sporadic gallbladder carcinoma and is of great value for ocurrence and improvement of sporadic gallbladder carcinoma.关键词
胆囊癌/hMLH1基因/hMSH2基因/免疫组化Key words
Gallbladder carcinoma hMLH1 hMSH2 Immunohistochemical引用本文复制引用
张国强,王晔恺,周吉航,卢海英..散发性胆囊癌hMLH1和hMSH2蛋白表达检测及其临床意义[J].浙江医学,2012,34(6):417-419,421,4.
