肿瘤防治研究2012，Vol.39Issue(2)：173-176,4.DOI:10.3971/j.issn.1000-8578.2012.02.014
三阴性乳腺癌的预后与上皮间叶转化的相关性
Prognosis of Triple-negative Breast Cancer and Its Relevance to Epithelial-mesenchymal Transitions
摘要
Abstract
Objective To investigate the prognoS1s of triple-negative breast cancer and its relevance to epi-thelial-mesenchymal tranS1tion(EMT). Methods Two hundred and forty patients of breast cancer were clasS1fied into 3 groups .triple-negative group, receptor poS1tive group and Her-2 poS1tive group .according to the expresS1on of estrogen receptor and progesterone receptor as well as Her-2 protein. Paraffin-embedded specimens of the primary tumors were collected and tissue micro-array blocks were constructed. Vim-entin expresS1ons were detected by imunohistochemistry. The prognoS1s and vimentin expresS1on among the 3 groups were analyzed. Results The overall survival and the 5 year survival rate of triple-negative group were S1gnificantly decreased compared to receptor poS1tive group, but were not statistically different from those of Her-2 group. ConcluS1on The poor prognoS1s of triple-negative breast cancer was associated with EMT.关键词
乳腺肿瘤/预后/上皮间叶转化/波形蛋白Key words
Breast cancer/Prognosis/Epithelial-mesenchymal TranS1tion/ Vimentin分类
医药卫生引用本文复制引用
龚益平,漆楚波,王明伟,陈创,赵德绵,许娟,邵军,程洪涛,夏和顺..三阴性乳腺癌的预后与上皮间叶转化的相关性[J].肿瘤防治研究,2012,39(2):173-176,4.基金项目
湖北省自然科学基金资助项目(2009CDB333) （2009CDB333）
