肿瘤防治研究2012，Vol.39Issue(2)：181-184,4.DOI:10.3971/j.issn.1000-8578.2012.02.016
新型雌激素受体GPER在乳腺癌组织中的表达及与预后的相关性
No Correlation between Expression of GPER and Prognosis of Patients with Primary Breast Cancer
摘要
Abstract
Objective To research the relationships between expresS1on of G-protein coupled estrogen receptor (GPER) and patient prognoS1s in primary mammary cancers. Methods GPER from 241 tissues of primary breast cancer patients was detected by immunohistochemistry relationships between the expresS1on of GPER and each of clinicopathological factors were analyzed by Chi-square and t-test. After a median 44. 6 months follow-up, relationships between GPER expresS1on and patient prognoS1s were analyzed by Kaplan-Meier method. Results GPER expresS1on rate was 64. 7%. There was a S1gnificant relationship among GPER and Erα.PR(P<0. 05) .while no statistically association between GPER and HER-2 as well as other clinicopathological variables (patients age,menstruation status,tumor S1ze.TNM stage, histological grade and pathological type) (P>0.05). Disease-free survival and overall survival in patients with GPER + tumors were longer than those in patients with GPER-(P>0. 05). There was no marked association between GPER expresS1on and hormonal therapy reS1stance. ConcluS1on The expresS1on of GPER was not S1gnificantly related with most clinicopathological variables and impact on prognoS1s of breast cancers patients,also not an independent prognostic determinant for breast carcinoma.关键词
乳腺癌/雌激素受体/GPER/预后Key words
Breast carcinoma/Estrogen receptor/GPER/Prognosis分类
医药卫生引用本文复制引用
罗平,罗浩军,杨光伦,涂刚..新型雌激素受体GPER在乳腺癌组织中的表达及与预后的相关性[J].肿瘤防治研究,2012,39(2):181-184,4.基金项目
国家自然科学基金资助项目(30872520) （30872520）
教育部科学技术研究重点资助项目(208113) （208113）
重庆市自然科学基金资助项目(CSTC,2008BB5200) （CSTC,2008BB5200）
重庆市教委科技资助项目(KJ080327) （KJ080327）
