肿瘤防治研究2012，Vol.39Issue(2)：185-188,4.DOI:10.3971/j.issn.1000-8578.2012.02.017
血管生成素-2及其受体在卵巢癌组织中的表达及与血管生成的关系
Relationship between Expressions of Angiopoietin-2 and Its Receptors and Angiogenesis in Ovarian Cancer
杨素梅 1刘可玲 2王立敏 1高建宏 1李华 1高玉霞1
作者信息
- 1. 065000 河北廊坊,河北省廊坊市人民医院妇产科
- 2. 河北省香河县人民医院妇产科
- 折叠
摘要
Abstract
Objective To explore the correlations between the expresS1ons of Angiopoietin-2 ( Ang-2) and its receptor(Tie-2) and the microvessel denS1ty(MVD) ,as well as several clinicopathologic parameters in ovarian carcinomas. Methods The expresS1ons of Ang-2 and Tie-2 were detected By RT-PCR,and MVD by the immunohistochemical mothed in 25 specimens of normal ovaries,25 specimens of benign ovarian tumors and 65 specimens of ovarian cancer. Results The MVD in the ovarian cancer group was S1gnificantly higher than that in the benign ovarian tumors group(t = 2. 61 ,P<0. 05) .moreover there was a S1gnificantly varied MVD among different clinical stages of ovarian cancer(F= 4. 618,P<0. 05). Both poS1tive rate and level of Ang-2 mRNA were markedly highest in the ovarian cancer group than those in the benign ovarian tumors group and the control group(P<0. 05). There was a S1gnificant difference of Ang-2 mRNA in different clinical stages of ovarian cancer (0. 298 ± 0. 022 vs. 0. 206 ± 0. 086, P<0. 05). A poS1tive correlation was found between the MVD and the expresS1on level of the Ang-2 mRNA(rMV = 0. 685 ,P<0. 05). Tie-2 mRNA was only observed from 5 specimens of ovarian cancer. ConcluS1on Ang-2 was high-expresS1on, and associated with the increased formation of tumor blood vessels in ovarian cancer.关键词
卵巢癌/血管生成素-2/血管生成素-2受体/血管内皮生长因子/微血管密度Key words
Ovarian carcinoma/ Angiopoietin-2 (Ang-2 )/ Tie-2 /VEGF/MVD分类
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杨素梅,刘可玲,王立敏,高建宏,李华,高玉霞..血管生成素-2及其受体在卵巢癌组织中的表达及与血管生成的关系[J].肿瘤防治研究,2012,39(2):185-188,4.
