肿瘤防治研究2012，Vol.39Issue(2)：213-217,5.DOI:10.3971/j.issn.1000-8578.2012.02.024
COX-2-1195G＞A多态与结直肠癌易感性关系的Meta分析
Meta-analysis for Association between Polymorphism of COX-2 -1195G＞A and Colorectal Cancer Susceptibility
姚志文 1赵振龙 1姜玉梅 1米颖 1古妙宁1
作者信息
- 1. 510515 广州,南方医科大学南方医院麻醉科
- 折叠
摘要
Abstract
Objective To evaluate the association between COX-2 -1195G>A polymorphism and colorectal cancer susceptibility. Methods Literatures on the case-control studies on the association between COX-2 -1195G>A and colorectal cancer susceptibility, were collected from PUBMED and CBM database and then pooled odds ratio (OR) was assessed by Meta-analysis. We also performed subgroup analysis and senS1tivity analysis and publication bias test. Results S1x studies with 2854 cases and 4250 controls were enrolled in this Meta-analysis. The pooled OR of AA + AG genotype compared to GG genotype under dominant model was 1. 29(95 %CI: 1. 09-1. 54) with S1gnificant difference. ConcluS1on The COX-2 -1195G>A polymorphism was S1gnificantly association with the colorectal cancer susceptibility under the dominant model.关键词
COX-2-1195G＞A/多态/结直肠癌/Meta分析Key words
COX-2 -1195G>A/Polymorphism/Colorectal cancer/Meta-analysis分类
医药卫生引用本文复制引用
姚志文,赵振龙,姜玉梅,米颖,古妙宁..COX-2-1195G＞A多态与结直肠癌易感性关系的Meta分析[J].肿瘤防治研究,2012,39(2):213-217,5.
