中药材2012，Vol.35Issue(1)：53-56,4.
石南藤化学成分研究
Study on the Bioactive Constituents of Piper wallichii
摘要
Abstract
Objective: To investigate the bioactive constituents in the stem of Piper wallichii. Methods; Compounds were separated by column chromatography of silica gel, ODS-A and Sephadex LH-20. Their structures were elucidated based on spectral analysis. DP-PH scavenging activity and AchE inhibitory activity were tested. Results: 10 compounds were isolated and their structures were identified as 3 ,4-methylenedioxy-benzoic acid(l) , vanillic acid(2) , benzoic acid(3) , N-p-coumaroyltyramine(4) , futoenone(5) , futo-quinol(6), isofutoquinol A(7), 4-hydroxy- 3,5-dimethoxy-benzoic acid(8) , futoamide(9), dihydropiperlonguminine(lO). Conclusion; Compounds 1 ~6 are isolated from P. Wallichii for the first time. Vanillic acid(2)and 4-hydroxy- 3,5-dimethoxy-benzoic acid (8)show scavenging activity against DPPH radical with ED50 at 224. 33μg/mL and 11.44μg/mL, respectively. No compound shows inhibition activity against AchE.关键词
石南藤/化学成分/DPPH自由基清除活性/乙酰胆碱酯酶抑制活性Key words
Piper wallichii ( Miq. ) Hand. -Mazz. / Chemical constituents/ DPPH scavenging activity/ AchE inhibitory activity分类
医药卫生引用本文复制引用
赵国伟,夏文,陈萍,韩恩吉,向兰..石南藤化学成分研究[J].中药材,2012,35(1):53-56,4.基金项目
国家自然科学基金(30271647,81073005) （30271647,81073005）
山东省优秀中青年科学家科研奖励基金(BS2010YY032) （BS2010YY032）
