中药材2012，Vol.35Issue(1)：138-141,4.
β-环糊精与盐酸黄连碱包合物的制备及其结构研究
Preparation and Stuctural Behavior of the Inclusion Complex of β-Cyclodextrin and Coptisine Hydrochloride
摘要
Abstract
Objective:To optimize the preparation of Coptisine hydrochloride/β-cyclodextrin(β-CD) inclusion complex and analyze the structure of the inclusion complex. Methods: With encapsulation rate as the index of evaluation, different factors influencing the inclusion complex e. G. Temperature, inclusion time and cooling time were investigated; UV-vis, DSC, 1 H-NMR, and solubilization experiment were utilized to analyze the inclusion complex. Results: The optimum process was as follows: coptisine hydrochloride:β-CD (mol/mol) =1=2, 40℃, agitating for 2h and then cooling for 3d. Inclusion rate was 90.64%. Various characterization results showed that the inclusion equilibrium constant Ka was 3. 11×106 M-1 at 298K, the benzene ring of coptisine hydrochloride was included into the cavity of β-CD, furthermore, the thermal stability and water-solubility of coptisine hydrochloride was improved when it was included with β-CD. Conclusion; The 2: 1(molar ratio)complexes between β-CD and coptisine hydrochloride is formed, which improves the bioavailability of coptisine hydrochloride.关键词
β-环糊精/黄连碱/包合/增溶性Key words
β-cyclodextrin/ Coptisine hydrochloride/ Inclusion/ Solubility enhancement分类
医药卫生引用本文复制引用
陈鸿雁,金真,陈善全..β-环糊精与盐酸黄连碱包合物的制备及其结构研究[J].中药材,2012,35(1):138-141,4.基金项目
惠州学院博士科研启动基金(C510.0209) （C510.0209）
