中药材2012，Vol.35Issue(1)：141-144,4.
正交试验法优选姜黄素凝胶贴剂促渗剂
Effects of Penetration Enhancers on Curcumin Transdermal Drug Delivery
高振坤 1王兰 2张美1
作者信息
- 1. 临沂大学化学化工学院,山东临沂276005
- 2. 陕西科技大学生命科学与工程学院,陕西西安710021
- 折叠
摘要
Abstract
Objective;To study the effects of penetration enhancers and their combinations on the curcumine transdermal drug delivery (CUR-TDDS). Methods; The penetration rate of curcumin through rat skin in vitro was measured using Valia-Chien diffusion cells, and orthogonal design method was set up for experimental design. Results; The optimum penetration enhancers were; 3% hydroxypropyl beta cyclodextrins( HP-β-CD) , 9% borneol and 3% peppermint oil. Conclusion; The HP-β-CD has the most potent enhancing effect.关键词
姜黄素/促渗剂/体外Key words
Curcumin/ Penetration enhancers/ In vitro分类
医药卫生引用本文复制引用
高振坤,王兰,张美..正交试验法优选姜黄素凝胶贴剂促渗剂[J].中药材,2012,35(1):141-144,4.
