中医药学报2012，Vol.40Issue(1)：13-16,4.
清心开窍方挥发油对AD大鼠皮质GFAP、Aβ及βAPP表达的影响
Effect of Qingxin Kaiqiao Prescription and Volatile Oil on the Expression of GFAP、Aβ and βAPP in the Cortex of AD Rats
摘要
Abstract
Objective:To study the effect of Qingxin Kaiqiao prescription and volatile oil on the expression of GFAP,Ap and βAPP in the cortex of AD rats. Methods: Forty male SD rats were randomly divided into five groups: the control group, the model group, the Aricept group, the Qingxin Kaiqiao prescription group and the volatile oil group. AD was induced by Aβ25 - 35 injected into the bilateral amygdala to observe the spatial learning and memony ability and the expression of GFAβ, Aβ, pAPP and IL - 6by immunohistochemistry in the cortex of the animal. Results; Learning and memory ability of Qingxin Kaiqiao prescription group and volatile oil group were improved, and the expression of GFAP, Ap,pAPP and IL -6 in the cortex of AD rats decreased. Compared with comparison group, the difference was notable (P < 0. 05). Conclusion; Qingxin Kaiqiao prescription may obviously improve the learning and memory ability of rats with AD by decreasing the expression of GFAP, Aβ, βAPP and IL - 6 in the cortex.关键词
阿尔茨海默病/清心开窍方/胶质纤维酸性蛋白/淀粉样蛋白Key words
Alzheimer disease/ Qingxin Kaiqiao prescription/ Aglial fibrillary acidic protein/ Amyloid protein分类
医药卫生引用本文复制引用
朱未名,胡海燕,陈翔,王文花,张晓艳,楚生辉..清心开窍方挥发油对AD大鼠皮质GFAP、Aβ及βAPP表达的影响[J].中医药学报,2012,40(1):13-16,4.基金项目
国家自然科学基金资助项目(No.30973780) （No.30973780）
浙江省自然科学基金资助项目(No.Y2080273) （No.Y2080273）
温州市科技局资助项目(No.Y20080106) （No.Y20080106）
