摘要
Abstract
Objective: To study the effect of Sangao - Tea ( SGT) on the proceeding of Metabolic Syndrome ( MS) in rats induced by high fat - high carbo - high salt diet and its mechanism. Methods: Experimental rats were randomly divided into three groups: control group, model group and SGT group. Control group received normal diet and no treatment. The latter two groups were both fed with high fat - high carbo - high salt diet to induce MS and SGT group alone was administered SGT (ig). By the end of the 8th week, body weight, length, blood pressure, heart weight, fasting plasma glucose , fasting insulin, C - peptide, leptin and tumor necrosis factor - a ( TNF - a ) were detected, and Lee index and insulin action index were calculated. Results; By the end of the 8th week, the rats of model group were manifested as MS. Most statistic figures (insulin action index, body weight, blood pressure, heart weight, fasting plasma glucose, fasting insulin, C - peptide, leptin and TNF - a) showed no significant difference between control group and SGT group. Compared with model group, the insulin action index of SGT group increased (P < 0. 01 ) and body weight, Lee index, blood pressure, fasting plasma glucose, fasting insulin and TNF - a decreased ( P < 0. 01 or P < 0. 05 ). Conclusion: SGT can inhibit the proceeding of MS, which can be attributed to the tumor necrosis factor - a decreasing, leading to the increase of insulin action.关键词
中药/胰岛素抵抗/代谢综合征/肿瘤坏死因子α/实验研究Key words
Chinese medicine/ Insulin resistance/ Metabolic syndrome/ Tumor necrosis factor -α/ Experimental research分类
医药卫生
