癌变·畸变·突变2012，Vol.24Issue(2)：136-140,5.DOI:10.3969/j.issn.1004-616x.2012.02.013
氯氰菊酯对模式动物秀丽隐杆线虫生殖能力的损伤作用
Reduction of reproductive capacity of model organism Caenorhabditis elegans induced by cypermethrin exposure
摘要
Abstract
OBJECTIVE: To study the reproductive toxicity of cypermethrin exposure on Caenorhabditis elegans and explore the feasibility of using Caenorhabditis elegans as a model organism in reproductive toxicology. METHODS: L4 N2 hermaphrodites were exposed to cypermethrin at 0.08、0.8 and 8.0 mg/L for 24, 48, and 72 h. RESULTS: After exposure of 24 h, there was no significant change in the endpoints observed. After exposure of 48 h, together with the decrease in brood size, decreased relative length of secondary-lateral seminal vesicle oocyte and the number of egg in utero, reduced rate of egg-laying were observed in nematodes exposed to cypermethrin at certain experimental concentrations. After exposure of 72 h, significant decreases in brood size and relative length of secondary-lateral seminal vesicle oocyte were observed at 0.8 and 8.0 mg/L cypermethrin groups. CONCLUSION: Cypermethrin reduced the brood size through impairing the development of oocyte and egg. Meanwhile, Caenorhabditis elegans was sensitive to the exposure of cypermethrin and can be recommended to be used as a model organism in the field of reproductive toxicology.关键词
氯氰菊酯/秀丽隐杆线虫/生殖毒性/生殖能力Key words
cypermethrin/ Caenorhabditis elegans/ reproductive toxicity/ reproductive capacity分类
医药卫生引用本文复制引用
阮秦莉,王大勇,居静娟,李云晖,李晓波,刘冉,梁戈玉,张娟,浦跃朴,尹立红..氯氰菊酯对模式动物秀丽隐杆线虫生殖能力的损伤作用[J].癌变·畸变·突变,2012,24(2):136-140,5.基金项目
国家自然科学基金(81072258,30901167) （81072258,30901167）
江苏省自然科学基金(BK2009281,BK2010402) （BK2009281,BK2010402）
国家教育部博士点专项基金(20090092120055) （20090092120055）
