癌变·畸变·突变2012，Vol.24Issue(2)：148-150,3.DOI:10.3969/j.issn.1004-616x.2012.02.016
印加果油急性毒性和致突变性研究
Acute toxicity and mutagenicity of Sacha lnchi oil
黄超培 1傅伟忠 1彭亮 1王彦武 1何励 1李彬1
作者信息
- 1. 广西壮族自治区疾病预防控制中心,广西南宁530028
- 折叠
摘要
Abstract
OBJECTIVE: To study the safety of Sacha Inchi oil. METHODS: Oral toxicity test (3 administrations within 24 h, total dose 54 g/kg), Ames test (5000, 1000, 200, 40, 8 μg/plate), micronucleus test of bone marrow PCE cell and sperm shape abnormality test in mice (10, 5, 2.5 g/kg) were used to study the acute toxicity and mutagenicity of Sacha Inchi oil. RESULTS: The oral LD50 of Sacha Inchi oil in mice was more than 54 g/kg. No increase in the number of revertant colonies was found in Ames test. The micronucleus rates and sperm abnormality rates at all doses were not significantly different from the negative control. CONCLUSION: The Sacha Inchi oil when given orally showed no acute toxicity and mutagenicity under our experimental conditions.关键词
印加果油/急性毒性/致突变性Key words
Sacha Inchi oil/ acute toxicity/ mutagenicity分类
医药卫生引用本文复制引用
黄超培,傅伟忠,彭亮,王彦武,何励,李彬..印加果油急性毒性和致突变性研究[J].癌变·畸变·突变,2012,24(2):148-150,3.
