安徽农业大学学报2012，Vol.39Issue(3)：341-344,4.
1-脱氧野尻霉素对SAMP8小鼠感觉运动能力和体重的影响
Effects of 1-deoxynojirimycin on sensorimotor ability and body weight in SAMP8 mice
摘要
Abstract
In this study, the effects of long-term orally administered, an extract of Mulberry leaves I.e., 1-deoxynojirimycin (DNJ), on sensorimotor ability and body weight were explored in the SAMP 8 mice. The results showed that DNJ treated mice had no significant difference in the body weight compared to the age-matched control mice (P>0.05). The elderly control mice had significantly shorter balance time than the young mice in the beam walking and tightrope tasks (.Ps<0.05). However, the 20 mg-kg"'-d"' DNJ treated mice had significantly longer balance time than the age-matched control mice in the both tasks, so had the 10 mg-kg'l-d"1 DNJ treated mice in the tightrope task. Our results indicated that long-term oral administration of DNJ does not affect body weight but can attenuate age-related sensorimotor ability decline in SAMP8 mice.关键词
1-脱氧野尻霉素/小鼠/衰老/感觉运动,能力/体重Key words
1-DNJ/ aging/ mice/ sensorimotor/ ability/ body weight分类
农业科技引用本文复制引用
陶飞,何燕,杨启纲,王芳,陈勇平,陈贵海,魏兆军..1-脱氧野尻霉素对SAMP8小鼠感觉运动能力和体重的影响[J].安徽农业大学学报,2012,39(3):341-344,4.基金项目
安徽省高校省级自然科学重点项目(ZD2008007-1/2)和安徽省自然科学基金项目(09020103001)共同资助. （ZD2008007-1/2）
