安徽医科大学学报2012，Vol.47Issue(5)：508-510,3.
胃和弓状核中obestatin在摄食行为调节中的作用
The roles of obestatin in stomach and hypothalamic arcuate nucleus of mice on the regulation of feeding behaviour
摘要
Abstract
Objective To study the effects of change of feeding behaviour (including fasting and refeeding ) on the expression of obestatin in stomach and hypothalamic arcuate nucleus ( ARC ) of mice, to investigate the roles of obestatin on the regulation of food intake . Methods Fifty Kunming white male mice were divided into 5 groups in this study.Group A: fasted for 0 h, Group B: fasted for 24 h, Group C : fasted for 48 h, Group D: fasted for 72 h, Group E: refed for 4 h after 72 h fasted. The changes of the body weight in each group on different times of fast -ing and refeeding were obeserved.The expression of obestatin in the stomach and ARC were studied by the tech -nique of immunohistochemistry. Results Compared with Group A, the body weight was significantly reduced in Group B, C and D, and increased in Group E ( P < 0. 05 ). The expression of obestatin in the stomach and ARC in Group B showed no significant difference with Group E . Expressions of obestatin in the ARC and stomach correlated positively with the died body weights , and there were significant negative correlations with the variation of body weight Conclusion Obestatin expressions are change in the stomach and ARC after fasting and refeeding , which shows that obestatin may participate in the regulation of feeding behavior .关键词
obestatin/饥饿/进食/胃/弓状核Key words
obestatin/ fasting/ refeeding/ stomach/ arcuate nucleus分类
医药卫生引用本文复制引用
康冬梅,赵翠平,姚慧,黄大可,叶山东..胃和弓状核中obestatin在摄食行为调节中的作用[J].安徽医科大学学报,2012,47(5):508-510,3.基金项目
安徽省自然科学基金(编号:070413104) （编号:070413104）
