安徽医科大学学报2012，Vol.47Issue(7)：800-804,5.
奥曲肽对实验性肝纤维化大鼠瘦素及功能性瘦素受体表达的影响
Effects of octreotide on expressions of leptin and obese receptor of experimental liver fibrosis in rats
摘要
Abstract
Objective To explore the effects of octreotide ( OCT ) on expressions of leptin and obese receptor ( OB-Rb ) of experimental liver fibrosis in rats. Methods 54 adult male SD rats were randomly divided into three groups: normal group, model group and OCT treatment group. The liver fibrosis models in rats were established by carbon tetrachloride ( CC14 ) with compound factors. OCT with abdominal subcutaneous injection was administered twice a day in OCT group. Three groups of rats were sacrificed randomly on the 2,4,6 weeks respectively. The levels of serum total bilirubin ( TBIL ), alanine aminotransferase ( ALT ), aspartate aminotransferase ( AST ), albumin ( ALB ), leptin and transforming growth factor betal( TGF-β1 ) were detected and the histopathology changes were observed; The immunohistochemical technique was used for detecting the leptin and OB-Rb protein expression. Results With the experimental time extending, the levels of serum TBIL, ALT, AST, leptin and TGF-β1 were increased, model group and OCT group were higher than those of normal group; The leptin and OB-Rb protein expressions increased. Compared with model group, the injury degree of hepatic function and histopathology of changes in OCT group decreased, the leptin and OB-Rb protein expression decreased. Conclusion OCT can improve the degree of hepatic function injury, delay the progress of liver fibrosis, which may be related with reducing the levels of TGF-β1 by inhibiting the expression of leptin and OB-Rb.关键词
奥曲肽/肝纤维化/瘦素/瘦素受体Key words
octreotide/ hepatic fibrosis/ leptin/ obese receptor分类
医药卫生引用本文复制引用
姚磊,张超,李方跃,鲁长文..奥曲肽对实验性肝纤维化大鼠瘦素及功能性瘦素受体表达的影响[J].安徽医科大学学报,2012,47(7):800-804,5.基金项目
安徽省卫生厅科研课题(编号:2008B064) （编号:2008B064）
