安徽医科大学学报2012，Vol.47Issue(7)：845-848,4.
左氧氟沙星三联7d方案和标准三联10d方案初次根除幽门螺杆菌的疗效观察
Therapeutic effect of levofloxacin-based triple regimen for 7 days and standard triple regimen for 10 days as first-line treatment in the management of Helicobacter pylori infection
罗玲玲 1张磊 1许建明 1胡咏梅 2卢春燕 1王志化1
作者信息
- 1. 安徽医科大学第一附属医院消化内科,合肥,230022
- 2. 安徽省消化系统疾病重点实验室,合肥,230022
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect and safety of levofloxacin-based triple regimen and standard triple regimen as the first-line therapy for Helicobacter pylorii. Hp ) infection. Methods 240 patients with Hp infection suffering from chronic gastritis or peptic ulcer were randomly assigned to group EAL( n = 120 )and group EAC( n = 120 ). Patients in group EAL received therapy with esomeprazole 20 mg plus amoxicillin 1 000 mg twice a day and levofloxacin 500 mg once a day for 7 days. Patients in group EAC received esomeprazole 20 mg, amoxicillin 1 000 mg and clarithromycin 500 mg, all twice a day for 10 days. Hp status was rechecked by 14C -urea breath test 4 weeks after the end of therapy. Results 219 patients completed the follow-up. The eradication rate in intention to treat( ITT ) and per protocol PP ) analysis were: group EAL 80. 0% ,88. 5% and group EAC 75. 8% , 82. 0% . No significant difference was found between the two triple therapies( P = 0. 439 and 0. 149 respectively ). Single-factor logistic analyse suggested that the eradication rate of peptic ulcer patients was higher than that of chronic gastritis patients, the significant difference was found between the two types of diseases( P = 0. 032 ); Multifacto-rial logistic analyse suggested that the type of disease was the factor affecting the rate of eradication( OR =0. 370, P = 0. 032 ). The ratio of cost-effectiveness of group EAL was much lower than that of group EAC ( 302. 40 yuan RMB vs 860. 31 yuan RMB ). Conclusion A 7-day levofloxacin-based triple therapy can achieve good radication rate and it has short duration,few side effect and good tolerance. It is worthy to be extended as one effective therapy for the first-line anti-H treatment.关键词
幽门螺杆菌/左氧氟沙星/阿莫西林/克拉霉素Key words
Helicobacter pylori/ levofloxacin/ clarithromycin/ amoxicillin分类
医药卫生引用本文复制引用
罗玲玲,张磊,许建明,胡咏梅,卢春燕,王志化..左氧氟沙星三联7d方案和标准三联10d方案初次根除幽门螺杆菌的疗效观察[J].安徽医科大学学报,2012,47(7):845-848,4.
