安徽中医学院学报2012，Vol.31Issue(3)：48-52,5.DOI:10.3969/j.issn.1000-2219.2012.03.018
肾虚对恐惧记忆形成的影响及补肾方药调节作用的初步研究
Effects of Kidney-deficiency on Formation of Fear Memory and Regulation of Kidney-tonifying Prescription: A Pilot Study
摘要
Abstract
Objective To observe the effects of kidney-deficiency and kidney-tonifying prescriptions on the formation of fear memory in rats . Methods Four-month old Sprague-Dawley (SD ) rats were used as controls .Two kinds of kidney-deficiency rat models induced by naturally aging and sexual exhaustion were employed . Rats were trained by conditioned stimulus (CS ) and unconditioned stimulus (US ) jointly or singly . The kidney-deficiency rats were treated with 2 .025 g/kg Guilu Erxian Gao (a patent traditional Chinese extract ) and 0 .06 g/kg total flavonoids of Epimedium , respectively . Average freezing time percentage (freezing% ) was examined in rats of each group . Results CS combined with US could significantly enhance freezing% in young rats and kidney-deficiency rats ( P＜0 .05 ) . Freezin% was significantly increased in kidney -deficiency rats ( P＜0 .05 ) . Kidney-tonifying prescriptions could significantly decrease freezing% in kidney-deficiency rats . Conclusion Kidney-deficiency could enhance conditioned fear memory caused by combined stimulus of CS and US . Kidney-tonifying prescriptions could inhibit the formation of fear memory of kidney -deficiency rats .关键词
条件性恐惧/肾虚/补肾Key words
conditioned fear / kidney-deficiency / kidney-tonifying分类
医药卫生引用本文复制引用
吴丽丽,严灿,刘书考..肾虚对恐惧记忆形成的影响及补肾方药调节作用的初步研究 [J].安徽中医学院学报,2012,31(3):48-52,5.基金项目
国家自然科学基金(30873207) （30873207）
