首页|期刊导航|北京大学学报（医学版）|全国多中心类风湿关节炎冠心病危险因素的现况调查

全国多中心类风湿关节炎冠心病危险因素的现况调查

李春李晓峰王莉枝王彩虹王永福杨荣王国春卢昕朱平陈丽娜靳洪涛王秀茹刘金婷刘湘源孙琳陈海英魏平王俊祥崔刘福舒荣刘白鹭张卓莉唐熠达李光韬李振彬杨静李俊芳贾彬张风肖陶杰梅韩淑玲林金盈韦美秋安媛刘晓敏柯丹胡绍先叶丛杨岫岩李昊黄慈波高明赖蓓李兴福周云杉宋立军王轶王晓元穆荣苏茵栗占国郭时伟张晓盈段天骄朱佳鑫

北京大学学报（医学版）2012，Vol.44Issue(2)：176-181,6.

北京大学学报（医学版）2012，Vol.44Issue(2)：176-181,6.DOI:10.3969/j.issn.1671-167X.2012.02.004

全国多中心类风湿关节炎冠心病危险因素的现况调查

A multicenter study of coronary artery disease and its risk factors in rheumatoid arthritis in China

李春 ¹李晓峰 ²王莉枝 ³王彩虹 ³王永福 ³杨荣 ⁴王国春 ⁴卢昕 ⁵朱平 ⁵陈丽娜 ⁶靳洪涛 ⁶王秀茹 ⁷刘金婷 ¹刘湘源 ²孙琳 ⁷陈海英 ⁸魏平 ⁸王俊祥 ⁹崔刘福 ⁹舒荣 ⁹刘白鹭 ¹⁰张卓莉 ¹⁰唐熠达 ¹⁰李光韬 ¹¹李振彬 ¹²杨静 ¹¹李俊芳 ¹³贾彬 ¹³张风肖 ¹⁴陶杰梅 ¹⁴韩淑玲 ¹⁵林金盈 ¹⁵韦美秋 ¹⁶安媛 ¹⁷刘晓敏 ¹⁷柯丹 ¹胡绍先 ¹⁸叶丛 ¹⁸杨岫岩 ¹⁹李昊 ¹⁹黄慈波 ²⁰高明 ²⁰赖蓓 ²¹李兴福 ²¹周云杉 ²¹宋立军 ²²王轶 ¹王晓元 ²²穆荣 ²³苏茵 ²³栗占国 ¹郭时伟 ¹张晓盈 ¹段天骄 ¹朱佳鑫¹

作者信息

1. 北京大学人民医院风湿免疫科,北京100044
2. 北京大学首钢医院多顶街社区卫生中心全科
3. 山西医科大学第二医院风湿免疫科,太原030001
4. 包头医学院第一附属医院风湿免疫科,包头014010
5. 中日友好医院风湿免疫科,北京100029
6. 第四军医大学西京医院风湿免疫科,西安710032
7. 河北医科大学第二医院风湿免疫科,石家庄050000
8. 北京大学第三医院风湿免疫科,北京100191
9. 河北医科大学第三医院风湿免疫科,石家庄050051
10. 华北煤炭医学院附属开滦医院风湿免疫科,唐山063000
11. 北京大学第一医院风湿免疫科,北京100034
12. 中国医学科学院北京协和医学院阜外心血管病医院心内科,北京100037
13. 白求恩国际和平医院风湿免疫科,石家庄050082
14. 河北邯郸中心医院风湿免疫科,邯郸056001
15. 河北省人民医院风湿免疫科,石家庄050051
16. 北京大学首钢医院风湿免疫科,北京100144
17. 广西壮族自治区人民医院风湿免疫科,南宁530021
18. 北京顺义区医院风湿免疫科,北京101300
19. 华中科技大学同济医学院附属同济医院风湿免疫科,武汉430030
20. 中山医科大学附属第一医院风湿免疫科,广州510080
21. 北京医院风湿免疫科,北京100730
22. 山东大学齐鲁医院风湿免疫科,济南250012
23. 兰州大学第二医院风湿免疫科,兰州730030
折叠

摘要

Abstract

Objective;To learn about the prevalence and risk factors of coronary artery disease (CAD) in rheumatoid arthritis ( RA). Methods; Data were obtained from a 12-month retrospective investigation of the patients with RA, randomly selected from Departments of Rheumatology and Immunology in 21 big hospitals in China. The data were collected about their social conditions, clinical conditions, medications associated with RA, such as disease modifying anti-rheumatic drugs (DMARDs), non steroidal anti-inflammatory drugs (NSAIDs), glucocorticoid, biologic agents. A nonparameter test and multivariate logistic regression analysis were performed. Results; In the study, 960 patients were enrolled. The prevalence of CAD was 3. 5% in China, which was obviously higher than that of normal people. The prevalence of overweight and obesity, smoking, hypertension, diabetes mellitus, hypercholesterolemia and cerebrovascular disease were 35. 1% , 12.3% , 17.0% , 7.7% , 0.4% and 3.0% , respectively. Compared with the control group, the CAD group had higher age [ (64. 7 ?.3) years t? (52. 3 ?14. 0 ) years,P <0.001 ] , more rheumatoid nodules (14. 7% vs. 3. 1% ,P =0. 005) , lower rate of hydroxy-chloroquine ( HCQ) use (5. 9% vs. 22.6% ,P =0.021) , higher prevalence rates of lung interstitial disease (17.5% 玸. 7. 0% , P < 0.001 ) , diabetes mellitus and hypertension (29. 4% vs. 7. 0% , P < 0.001; 38. 2% vs. 16. 2% ,P =0.001). There was no obvious correlation of CAD in RA with joint deformity , rheumatoid factor ( RF) titer, glucocorticoid use, hypercholesterolemia and body mass index (BMI). Multivariate analysis showed higher age, diabetes mellitus and hypertension were independent predictors of CAD, and the use of HCQ was a protective factor of CAD. Conclusion; The prevalence of CAD is 3.5%. Higher age, diabetes mellitus and hypertension are independent predictors of CAD, and the use of HCQ is a protective factor of CAD.

关键词

关节炎,类风湿/冠心病/危险因素/患病率

Key words

Arthritis/ rheumatoid / Coronary artery disease/ Risk factors/ Prevalence

分类

医药卫生

引用本文复制引用

李春,李晓峰,王莉枝,王彩虹,王永福,杨荣,王国春,卢昕,朱平,陈丽娜,靳洪涛,王秀茹,刘金婷,刘湘源,孙琳,陈海英,魏平,王俊祥,崔刘福,舒荣,刘白鹭,张卓莉,唐熠达,李光韬,李振彬,杨静,李俊芳,贾彬,张风肖,陶杰梅,韩淑玲,林金盈,韦美秋,安媛,刘晓敏,柯丹,胡绍先,叶丛,杨岫岩,李昊,黄慈波,高明,赖蓓,李兴福,周云杉,宋立军,王轶,王晓元,穆荣,苏茵,栗占国,郭时伟,张晓盈,段天骄,朱佳鑫..全国多中心类风湿关节炎冠心病危险因素的现况调查[J].北京大学学报（医学版）,2012,44(2):176-181,6.

基金项目

十一五"国家科技支撑计划项目(2008BA159B01)资助（2008BA159B01）

北京大学学报（医学版）

OA北大核心CSCDCSTPCD

ISSN：1671-167X

访问量1

下载量0

段落导航