摘要
Abstract
Objective: To investigate the significance of autoantibodies in patients with primary biliary cirrhosis (PBC). Methods; A anti-mitochondrial antibodies-M2( AMA-M2) , anti-BCOADC-E2 PDC-E2 OGDC-E2 antibodies (anti-3E/BPO) , anti-SPlOO antibodies (anti-SPlOO) , anti-promyelocytic leukemi-a ( anti-PML) , anti-gp210 antibodies (anti-gp210) ,and anti-Ro-52 were detected respectively in 330 suspected PBC cases by Western blotting. Results; ( 1) The sensitivity/specificity rates of AMA-M2,an-ti-3E/BPO,anti-SP100,anti-PML,anti-gp210,and anti-Ro-52 were 85.3%/84.8% , 79.4%/93.2 % , 35.3%/98.0% , 41.2%/96.3% , 44. l%/96.6% ,61. 8%/68.6% respectively; AMA-M2 were combined with the other antibodies. The specificity rates in the series tests were 94. 9% , 99. 3% , 99. 3 % , 98. 3% , and 92. 2% , while the sensitivity rates in the parallel tests were 91. 2% , 94. 1% , 94. 1% , 94.1% , and 1.2% .respectively . (2)There were 5 cases of AMA-M2 negative in patients with PBC,in-
eluding 60% (3/5) cases of anti-gp210, anti-SPl00 and anti-PML positive respectively. Conclusion; ( 1 ) AMA-M2 were more sensitive than other antibodies, while the specificity rates of anti-3E/BPO , an-ti-SPlOO, anti-PML, and anti-gp210 were higher than that of AMA-M2; Parallel tests helps to exclude the suspected PBC cases and series tests could be useful in clinics to confirm the PBC cases. (2) Anti-gp210, anti-SPlOO, anti-PML antibodies appear to be more common in AMA-M2 negative PBC patients than in those who are AMA-M2 positive, and their presence in AMA-M2 negative PBC patients contributes to the PBC diagnosis.
关键词
肝硬化,胆汁性/自身抗体/诊断Key words
Liver cirrhosis, biliary/ Autoantibodies/ Diagnosis分类
医药卫生
