波谱学杂志2012，Vol.29Issue(2)：216-223,8.
NMR实验参数对IBP-血浆相互作用个性化差异研究的影响
Effects of NMR Parameters on Study of Individual Variations of Plasma-Ibuprofen Interactions
摘要
Abstract
The interactions between drug and plasma proteins play a major role in drug absorption, metabolism and its efficacy. Previous reports demonstrated that diffusion-and relaxation-weighted NMR combined with principal components analysis (PCA) could be used to characterize individual variations of plasma-drug interactions. In this research, using plasma with/without drug ibuprofen (IBP) as model, the NMR parameters including diffusion time, gradient strength for diffusion-weighted NMR and echo time for relaxation-weighted NMR were optimized. The results showed that gradient strength of 1. 52 X l0T-3T/cm~l. 90 X 10~3T/cm under diffusion time of 0. 1 s~0. 14 s for diffusion-weighted NMR and echo time of 70 ms~110 ms for relaxation-weighted NMR are optimal for characterizing individual variations of plasma-drug interactions.关键词
核磁共振(NMR)/个性化差异/扩散加权谱/弛豫加权谱/主成分分析/血浆/布洛芬Key words
nuclear magnetic resonance( NMR) / individual variation/ diffusion-weighted NMR/ relaxation-weighted NMR/ principal components analysis/ plasma/ ibuprofen分类
数理科学引用本文复制引用
杜媛媛,纪竹生,刘买利..NMR实验参数对IBP-血浆相互作用个性化差异研究的影响[J].波谱学杂志,2012,29(2):216-223,8.基金项目
国家自然科学基金资助项目(20975112). （20975112）
