重庆医学2012，Vol.41Issue(17)：1693-1695,3.DOI:10.3969/j.issn.1671-8348.2012.17.008
术前放疗联合手术治疗Ⅱ期宫颈癌临床分析
Clinical analysis on preoperative radiotherapy plus surgery in treating stage Ⅱcervical cancer
马代远 1杜国波 1谭榜宪 1柳弥 1周业琴 1廖碧霞1
作者信息
- 1. 川北医学院附属医院肿瘤科,四川南充,637000
- 折叠
摘要
Abstract
Objective To investigate the effect,late adverse reactions and prognostic factors of simple preoperative radiotherapy plus surgery in treating stage Ⅱ cervical cancer. Methods 82 cases of pathologically diagnosed stage Ⅱ cervical cancer were performed preoperative radiotherapy plus surgery. Radioetherapy: the total dose of extraorgan radiation to whole pelvic cavity was 20 - 40 Gy with 6MV X-ray and the median dose was 40Gy,simultaneously,the 192Ir afterloading treatment was enforcing once a week (the dose at A point was 6-8Gy every time,2-4 times). Operation;60 cases were performed radical hysterectomy and pelvic cavity lymph nodes dissection and 22 cases were performed subradical hysterectomy and pelvic cavity lymph nodes dissection. The surgery was followed in 3 weeks after radiotherapy. Results The 5 - year control rate was 85. 4% , the total survival rate was 78. 0% and the survival rate without tumor was 75. 6%. The incidence rate of late reactions ≥ gradeⅡ was 8. 5% for bladder and 12. 2% for rectum. The incidence rate of lower extremity edema was 8. 5%. The univariate analysis showed that the patients with HGB≥ 110g/L(x2 = 6. 736 , P = 0. 009) , without operation residual (x2=5.818,P = 0. 016), without pelvic cavity lymph nodes metastasis (x2=8. 924 ,P = 0. 004)and with negative postoperative pathologic results(x2 = 12. 177,P = 0. 000) had favorable prognosis. Conclusion Preoperative radiotherapy plus surgery is a feasible treatment mode to stage fJ cervical carcinoma. The late adverse reactions are tolerable. The HGB level,operation residual and postoperative pathologic results are independent prognosis factors.关键词
宫颈癌/术前放射治疗/手术/预后分析Key words
cervical carcinoma/preoperative radiation/prognosis factors引用本文复制引用
马代远,杜国波,谭榜宪,柳弥,周业琴,廖碧霞..术前放疗联合手术治疗Ⅱ期宫颈癌临床分析[J].重庆医学,2012,41(17):1693-1695,3.
