结直肠肛门外科2012，Vol.18Issue(2)：98-101,4.
CD24mRNA和PDGF-D mRNA在结直肠癌组织中的表达及意义
The signification of CD24 mRNA and PDGF-D mRNA expression in Colorectal Carcinomas
张双科 1任明慧 1姜海毅 2陈磊 2李杨2
作者信息
- 1. 泰山医学院,山东泰安,271016
- 2. 青岛市市立医院,山东青岛市,266011
- 折叠
摘要
Abstract
Objective To detect the expression level of CD24mRNA and PDGF-D mRNA in Colorectal Carcinomas , to explore theirsignification in the development and progression of Colorectal Carcinomas. Methods Collecting 46 cases of Colorectal Carcinomas and corresponding normal tissues, RT-PCR was used to detect the expression level of CD24mRNA and PDGF-D mRNA in all cases. SPSS17. 0 was used to analyze their correlation with clinicopathological factors of Colorectal Carcinomas. Results (T) The expression of CD24mRNA and PDGF-D mRNA were higher in Colorectal Carcinomas than that in corresponding normaltissues. ·The expression of CD24mRNA was correlated with tumor invasion) P <0. 05) , and was not correlated with age, degree of differentiation, Duke's stages and diameter of tumor( P >0. 05). The expression of PDGF-D mRNA was correlated with age, degree of differentiation, Duke's stages( P <0. 05) , and was not correlated with tumor invasion and diameter of tumor. Correlation analysis showed that there was a positive correlation between CD24mRNA and PDGF-D mRNA in Colorectal Carcinomas. Conclusion High expression of CD24mRNA and PDGF-D mRNA were closely correlated with the occurrence and development of Colorectal Carcinomas. They might serve as a new indicator for early diagnosis and predicting the prognosis of Colorectal Carcinomas. They might provide new ideas for targeted therapy of Colorectal Carcinomas.关键词
结直肠癌/CD24/PDGF-D/mRNAKey words
Colorectal Carcinomas/CD24/PDGF-D/mRNA分类
医药卫生引用本文复制引用
张双科,任明慧,姜海毅,陈磊,李杨..CD24mRNA和PDGF-D mRNA在结直肠癌组织中的表达及意义[J].结直肠肛门外科,2012,18(2):98-101,4.
