中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(6)：353-355,3.DOI:10.1007/sl0330-012-0908-x
Assistant radiotherapeutic effect of Jiaqi Mixture on tumor-bearing mice
Assistant radiotherapeutic effect of Jiaqi Mixture on tumor-bearing mice
Shichao Wei 1Chenyu Zhang 1Guang Du 1Baoxia Ma1
作者信息
- 1. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- 折叠
摘要
Abstract
Objective: The aim was to study the assistant radiotherapeutic effect of Jiaqi Mixture (JQM) on Ehrlich's ascites carcinoma (EAC) mice. Methods: The EAC-cancer model was made up with Kunming mice. The tumor-bearing mice were treated with whole body exposure (8 Gy) and intragastric administration of JQM, and the changes of tumor weight, the total number of white blood cells (WBC) and immune system were observed. Results: The average tumor weight, WBC, spleen coefficient, the stimulation index (SI) of Con A and LPS and the natural killing (NK) cell activity of mice decreased in some degree after radiotherapy, but the average tumor weight decreased more obviously in radiotherapy + medicine groups (compared with tumor control group, P < 0.05); and the other above indexes were much higher in radiotherapy + medicine groups than those in radiotherapy groups (P < 0.05-0.01). Conclusion: It was suggested that JQM can enhance the effect of radiation therapy and protect the normal immune system caused by radiation therapy.关键词
Jiaqi mixture/radiotherapy/blastisation of lymphocyte/NK cell activity/radioprotectionKey words
Jiaqi mixture/radiotherapy/blastisation of lymphocyte/NK cell activity/radioprotection引用本文复制引用
Shichao Wei,Chenyu Zhang,Guang Du,Baoxia Ma..Assistant radiotherapeutic effect of Jiaqi Mixture on tumor-bearing mice[J].中德临床肿瘤学杂志（英文版）,2012,11(6):353-355,3.
