首页|期刊导航|中德临床肿瘤学杂志（英文版）|Hematologic toxicity of gemcitabine: a comparison between fixed-dose rate infusion and thirty-minute infusion in the treatment of malignancy
中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(7)：414-418,5.DOI:10.1007/s10330-012-0992-y
Hematologic toxicity of gemcitabine: a comparison between fixed-dose rate infusion and thirty-minute infusion in the treatment of malignancy
Hematologic toxicity of gemcitabine: a comparison between fixed-dose rate infusion and thirty-minute infusion in the treatment of malignancy
摘要
Abstract
Objective: The aim of the study was to compare the hematologic toxicity of gemcitabine between fixed-dose rate (FDR) infusion and 30-minute standard infusion in the treatment of malignancy. Methods: The 25 malignancy patients confirmed by histopathology or cytology received single-agent gemcitabine or gemcitabine in combination with other chemo-therapeutic agents. These patients were randomly divided into gemcitabine 1000 mg/m2 on d1, d8 at a rate of 10 mg/m2/min arm (FDR arm) or 30 min arm (standard arm), every 21 days one cycle. Hematologic toxicity was evaluated at the end of each cycle. Results: The 13 of 25 patients received gemcitabine FDR therapy, a total of 28 cycles was completed, and 32 cycles in the others (12 of 25 patients) with the standard arm. All patients were evaluable for hematologic toxicity. The result showed that the grades 3–4 leucopenia was significantly different between the two arms (14.3% vs 0, P < 0.05), and no significant differences of neutropenia, thrombocytopenia and hemoglobin suppression of grades 3–4 (14.3% vs 3.1%, 10.7% vs 3.1%, 3.6% vs 9.4%, P > 0.05, respectively) were observed between the two arms, no grade 4 of hemoglobin suppression was observed. Conclusion: Hematologic toxicity of gemcitabine therapy at a fixed-dose rate for malignancy is tolerable.关键词
gemcitabine/fixed-dose rate (FDR)/malignancy/hematologic toxicityKey words
gemcitabine/fixed-dose rate (FDR)/malignancy/hematologic toxicity引用本文复制引用
Chunyan Li,Li Chu ,Hui Han,Xi Liu,Yuping Shen,Mantang Qiu,Qing Xu..Hematologic toxicity of gemcitabine: a comparison between fixed-dose rate infusion and thirty-minute infusion in the treatment of malignancy[J].中德临床肿瘤学杂志（英文版）,2012,11(7):414-418,5.基金项目
Supported by the grants of the National Natural Science Foundation of China (No.30872591) and Shanghai Science and Technology Commission (No.02.04.11.006). （No.30872591）
