儿科药学杂志2012，Vol.18Issue(3)：5-7,3.
孟鲁司特对幼年哮喘大鼠气道重塑的影响
The Effect of Montelukast Remodeling in Asthmatic Airway in Rats
摘要
Abstract
Objective: To explore the effect of montelukast in asthmatic airway remodeling in rats. Methods: Twenty four SD rats were randomly divided into three groups; model group, control group and montelukast treatment group. Model group and montelukast treatment group were administrated with Ovalbumin for 8 weeks, however, montelukast treatment group were given montelukast IS mg/kg through gastric lavage 2 hours before Ovalbumin sensitization. HE staining and image analysis were used to measure Wat/Pbm and Wam/Pbm, and hydroxyproline content were determined in different groups. Results; (1) The Wat/Pbm and Wam/Pbm, in the model group were (72. 53±5. 71) μm and (24. 57±2. 31) μm, and in montelukast treatment group were (63. 17±4. 99) μm and (16.31 ±2.14 ) μm. Either in model group or montelukast treatment group, the Wat/Pbm and Wam/Pbm, were obvious increased than those in control group (P<0. 05). However, the Wat/Pbm and Wam/Pbm in montelukast treatment group were lesser than those in model group ( P<0.05 ); ( 2 ) Hydroxyproline contents of lung tissue in both model and montelukast treatment group were increased than those in control group (P<0.01), and in model group were even higher ( P<0.01). Conclusions; Montelukast can inhibit the airway smooth muscle thickening and collagen deposition.关键词
哮喘/气道重塑/幼年/大鼠/孟鲁司特Key words
Asthma/ Airway remolding/ Young/ Rats/ Montelukast分类
医药卫生引用本文复制引用
魏兵,尚云晓,李淼,张晗,张克,马明..孟鲁司特对幼年哮喘大鼠气道重塑的影响[J].儿科药学杂志,2012,18(3):5-7,3.基金项目
辽宁省教育厅高等学校科研项目计划(项目编号:20060953). （项目编号:20060953）
