格列本脲治疗新生儿糖尿病2例报道及文献分析OACSTPCD
Follow-up Analysis of 2 Cases of Neonatal Diabetes Mellitus Treated with Glibenclamide
目的:总结新生儿糖尿病的临床特点,为临床提供诊疗经验.方法:对郑州市儿童医院内分泌科2010年2月～5月诊治的2例新生儿糖尿病患儿的临床资料进行分析、总结,并复习相关文献.结果:2例新生儿糖尿病患儿病初给予胰岛素治疗效果不佳,改为格列本脲后血糖控制良好,1例患儿治疗5个月停药,1例患儿持续应用小剂量格列本脲维持血糖控制良好.结论:新生儿糖尿病当应用胰岛素治疗效果不佳时,可能为KCNJ11基因突变所致,若无条件对新生儿糖尿病患儿进行基因检测,可试验性应用格列本脲治疗.
Objective: To provide experiences of diagnosis and treatment for clinicians through summarizing the clinical characteristics of neonatal diabetes mellitus. Methods; Two cases in department of endocrinology of Zhengzhou Children' s Hospital were recruited from Feb. 2010 to May 2010. Clinical data of them were analyzed and summarized. Related documents were also studied. Results: Because of the poor results of insulin treatment, two cases were switched to glib…查看全部>>
刘芳;卫海燕;陈永兴
河南省郑州市儿童医院,河南郑州450052河南省郑州市儿童医院,河南郑州450052河南省郑州市儿童医院,河南郑州450052
医药卫生
新生儿糖尿病格列本脲胰岛素
Neonatal Diabetes mellitus Glibenclamide Insulin
《儿科药学杂志》 2012 (3)
10-12,3
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