儿科药学杂志2012，Vol.18Issue(3)：36-38,3.
新生儿大肠埃希菌败血症40例临床分析
Neonatal Escherichia Coli Septicemia: A Study of 40 Cases
罗玉蓉1
作者信息
- 1. 四川省成都市妇女儿童中心医院,四川成都610091
- 折叠
摘要
Abstract
Objective: To investigate the drug sensitivity of neonatal Escherichia coli septicemia in order to provide guidance for reasonable treatment. Methods-. Blood samples of clinical septicemia neonates in our hospital from January 2007 to December 2010 were cultured, isolated and tested, and those with positive blood culture results in Escherichia coli were selected to perform susceptibility tests and clinical analysis. Results: It was found that all the Escherichia coli strains were completely sensitive to carbapenems such as imipenem and meropenem. To cephamycins such as cefoxitin, the sensitivity rate was 75.0%. To the compound with enzyme inhibition, such as piperacillin tazobactam and ticarcillin clavulanate, the sensitivity rate was 87.5%. To aminoglycosiders and quinolones, which were hardly used in the newborn, the sensitivity rates were 62. 5% ~93.8%. The Escherichia coli were resistant to penicillin, cephalosporins, and completely resistant to ampieillin. The tendency of producing ESBLs had gradually risen. It was higher in the late onset sepsis than that in the early onset sepsis. But the curative effect of the early onset sepsis was worse than the late onset sepsis. Conclusions; The clinical manifestations of neonatal Escherichia coli septicemia are usually non-specific, but its complications are severe. Part of the Escherichia coli strains were ESBLs and insensitive to the commonly used antibiotics. It is suggested the antibiotics should be used according to the drug sensitivity results.关键词
新生儿/大肠埃希菌/败血症Key words
Newborn/ Escherichia coli/ Septicemia分类
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罗玉蓉..新生儿大肠埃希菌败血症40例临床分析[J].儿科药学杂志,2012,18(3):36-38,3.
