辐射防护2012，Vol.32Issue(2)：81-87,7.
Tip60过表达对细胞DNA辐射损伤修复及细胞周期的影响
The Effects of Over-expressing Tip60 on Cellular DNA Damage Repair and Cell Cycle Progression
摘要
Abstract
To investigate the effects of Tip60 on DNA damage repair,cell cycle and the related mechanism as well,the proliferative activity,DNA double strand break（DSB） repair competency and cell cycle arrest were analyzed in stable Tip60-overexpression U2OS cells established by transfecting with exogenous Tip60 gene.It was found that the overexpression of Tip60 inhibited the proliferative activity but increased the DNA damage repair competency.The radiation-induced G2/M arrest was prolonged in Tip60 over-expressed U2OS cells,which was associated with a decreasing level of cell cycle checkpoint protein Cyclin B/CDC2 complex.关键词
Tip60/DNA双链断裂/DNA修复/周期阻滞Key words
Tip60/DNA double strand break/DNA repair/cell cycle arrest分类
生物科学引用本文复制引用
樊嵘,刘晓丹,王豫,徐勤枝,周平坤..Tip60过表达对细胞DNA辐射损伤修复及细胞周期的影响[J].辐射防护,2012,32(2):81-87,7.基金项目
国家自然科学基金资助项目 （）
