分析测试学报2012，Vol.31Issue(4)：475-479,5.DOI:10.3969/j.issn.1004-4957.2012.04.019
ICP-OES法快速检测药品中催化剂残留的14种重金属元素
Rapid Determination of 14 Heavy Metal Elements of Catalysts Residues in Pharmaceutical Ingredients by ICP- OES Method
张玲帆 1王艳萍 2刘鑫 1陶卫 1张磊 1张文清1
作者信息
- 1. 华东理工大学化学与分子工程学院,上海200237
- 2. 安捷伦科技有限公司生命科学与化学分析部,上海200233
- 折叠
摘要
Abstract
An inductively coupled plasma optical emission spectrometric (ICP - OES) method was developed for the determination of metallic impurities in pharmaceutical ingredients. The samples were directly dissolved with organic mixed solvent (DMSO : H2O =4 : 1). The conditions of instrument were optimized, and the 14 metal elements listed in EMEA guidance could be rapidly analyzed by the method. The detection limits were less than 0. 30 mg/kg, and the recoveries of the 14 metal elements ranged from 90% to 115% . The data was compared with those obtained from the different treatment methods. The results showed that the method, with the advantages of simplicity, easy operation and high accuracy, was suitable for the quick determination of multi-elements in large quantities of samples.关键词
ICP-OES/二甲基亚砜/金属催化剂/药物/检测/重金属Key words
ICP-OES/ dimethyl sulfoxide/ metal catalysts/ pharmaceutical ingredients/ determination/ heavy metal分类
化学化工引用本文复制引用
张玲帆,王艳萍,刘鑫,陶卫,张磊,张文清..ICP-OES法快速检测药品中催化剂残留的14种重金属元素[J].分析测试学报,2012,31(4):475-479,5.
