高等学校化学学报2012，Vol.33Issue(6)：1151-1157,7.DOI:10.3969/j.issn.0251-0790.2012.06.006
多苯并咪唑锰(Ⅱ)配合物的合成及对DNA凝聚的促进作用
Synthesis and Properties on Promoting DNA Condensation of Polybenzimidazole Mn( Ⅱ ) Complexes
摘要
Abstract
Complexes [ Mn( DTPB)Ac] Ac·8H2O(1) and [ Mn2(DTPB) ( NO3 )2( H2O)2 ] [Mn2(DTPB)·( NO3 )2·( H2O)·( CH,OH) ] ( N03 )4 -5CH3OH -H2O(2) were synthesized via 1,1,4,7,7-pentakis( lff-ben-zimidazol-2-ylmethyl)-l ,4,7-triazaheptane(DTPB) as the main ligand and characterized by X-ray diffraction. The interaction between complexes 1 or 2 and DNA, examined by UV-Vis absorption spectra and viscosity experiments, indicated that the two Mn( II ) complexes have strong affinity for DNA. The interaction mechanism of the complexes with DNA was discussed. These Mn( II ) complexes can promote DNA condensation under neutral conditions, as illustrated by gelose gel electrophoresis and right angle light scattering ( RALS). The morphologies of the DNA condensates were observed by transmission electron microscopy(TEM).关键词
1,1,4,7,7-五(2-苯并咪唑甲基)-二乙基三胺/锰(Ⅱ)配合物/晶体结构/DNA凝聚Key words
1,1,4,7,7-Pentakis (1 H-benzimidazol-2-ylmethyl) -1,4, 7 -triazaheptane ( DTPB )/Mn ( II ) complex/Crystal structure/DNA condensation分类
化学化工引用本文复制引用
黄雪英,孟祥高,张妍,王莉,刘长林..多苯并咪唑锰(Ⅱ)配合物的合成及对DNA凝聚的促进作用[J].高等学校化学学报,2012,33(6):1151-1157,7.基金项目
国家自然科学基金(批准号:20971049, 21001047)和华中师范大学博士基金(批准号:CCNU10A01010)资助. （批准号:20971049, 21001047）
