广东医学2012，Vol.33Issue(10)：1400-1403,4.
ADAM17与HER-2在乳腺癌中表达的意义及相关性
Expression of ADAM17 and HER-2 in breast cancer and their correlation
摘要
Abstract
Objective To investigate the expressions and clinical significance of a disintegrin and metalloprotein- ase 17 ( ADAM17) and human epidermal growth factor receptor - 2 ( HER - 2) in human breast cancer; and to investigated the correlation between ADAM17 and HER - 2. Methods The expression of ADAM17 and HER - 2 in the normal breast tissue and breast cancer were detected by immunohistochemical staining. Results ADAM17 and HER - 2 were negatively or weakly expressed in normal breast tissue, while the expression was positive in breast cancer. The ADAM17 and HER - 2 positive expression rates in breast cancer were significantly higher than those in normal tissues ( P ＜0. 05 ). There was no significant correlation between expression of ADAM17 or HER - 2 and the age of patients or tumor size. However, there was significant correlation between the expressions of ADAM17 or HER -2 and lymph node metastasis. Conclusions The expressions of ADAM17 and HER -2 are associated with the biological characteristics of breast cancer, indicating possible lymph node metastasis. Thus ADAM17 provides new target for breast cancer treatment.关键词
解聚素-金属蛋白酶17/人表皮生长因子受体2/乳腺癌Key words
a disintegrin and metalloprotease - 17/human epidermal growth factor receptor -2/breast cancer引用本文复制引用
孙泽辉,张雪鹏,韩旭,胡宝山..ADAM17与HER-2在乳腺癌中表达的意义及相关性[J].广东医学,2012,33(10):1400-1403,4.基金项目
河北省自然科学基金资助项目(编号:C2010001767) （编号:C2010001767）
