国际医药卫生导报2012，Vol.18Issue(7)：896-899,4.DOI:10.3760/cma.j.issn.1007-1245.2012.07.003
HPV-18病毒E2与E6在宫颈病变中的表达与意义
Expressions of human papillomavirus-18 E2 and E6 in cervical lesions
摘要
Abstract
Objective To investigate the expressions of human papillomavirus-18 E2 and E6 oncogene in cervical lesions and its correlation with cervical carcinogenesis.Methods The expressions of HPV- 18 E2 and E6 gene in the tissues from 15 cases of cervicitis,19 cases of CIN Ⅰ,17 cases of CIN Ⅱ,20 cases of CIN Ⅲ,and 24 cases of invasion cervical carcinoma with HPV-18 infection were detected by reverse transcription polymerase chain reaction.Results The positive rate of E2 gene expression in groups of cervicitis,CIN Ⅰ,CIN Ⅱ,CIN Ⅲ and invasion cervical carcinoma were 93.3 ％,94.7 ％,58.8％,20.0％ and 0％ respectively,and thatofE6genewere6.7％,5.3％,41.2％,85.0％and 100％respectively.No significant differences of E2 and E6 gene expressions were found between groups of cervicitis and CIN Ⅰ ( P＞ 0.05 ).However,there were significant differences between any two groups of CIN Ⅰ,CIN Ⅱ,CIN Ⅲ and invasion cervical carcinoma ( P＜ 0.05 ).The expression of E6 gene was inversely correlated with expression of E2 gene ( r=-0.728, P ＜ 0.01 ).Conclusions Deletion of HPV-18 E2 and overexpression of E6 which has been regarded as a key step in malignant transformation of cervical cells inducted by HPV may play an important role in cervical carcinogenesis.Detection of levels of HPV-18 E2 and E6 expression might be clinically valuable in the prediction of cervical carcinogenesis and the evaluation of prognosis in CIN.关键词
人乳头瘤病毒18/E2/E6/宫颈上皮内瘤变/宫颈癌Key words
HPV-18/E2/E6/Cervical intraepithelial neoplasia/Cervical carcinoma引用本文复制引用
黄卓敏,王楚莹,古衍,姚吉龙,谢建生..HPV-18病毒E2与E6在宫颈病变中的表达与意义[J].国际医药卫生导报,2012,18(7):896-899,4.基金项目
深圳市科技计划立项项目(201003104 （）
201102091) （）
