硅酸盐学报2012，Vol.40Issue(2)：306-311,6.
多孔球形羟基磷灰石生物材料的制备
Preparation of Porous Spherical Hydroxyapatite Biomaterial
摘要
Abstract
The preparation of porous spherical hydroxyapatite （HAP） biomaterial used as drug delivery vehicle was investigated. The porous spherical HAP biomaterial was synthesized by a microemulsion reaction using porous spherical CaCO3 and Na2HPO4 as reac- tants. The obtained HAP was characterized by scanning electron microscopy and X ray diffraction, respectively. The effects of sur- factant concentration, synthesis temperature and time on the purity, particle size and morphology of HAP were investigated. The for- mation mechanism of porous spherical HAP was discussed. The results show that the well-dispersed porous spherical hydroxyapatite biomaterial with the particle size in the range of 5 to 10 μm could be prepared at the synthesis temperature of 25 ℃, the surfactant concentration of 3 % and the reaction time of 30 h.关键词
羟基磷灰石/碳酸钙/多孔球形/药物载体Key words
hydroxyapatite/calcium carbonate/porous spherical/drug-delivery分类
医药卫生引用本文复制引用
杨辉,黄菲菲..多孔球形羟基磷灰石生物材料的制备[J].硅酸盐学报,2012,40(2):306-311,6.基金项目
陕西科技大学博士启动基金项目（BJ09-14）：陕西省教育厅自然科学专项基金（09JK307）资助项目. （）
