广东药学院学报2012，Vol.28Issue(1)：17-20,4.DOI:10.3969/j.issn.1006-8783.2012.01.005
碳化硅管中微波辅助制备甲硝唑半抗原
Microwave-assisted synthesis of hapten of metronidazole in silicon carbide reactor
摘要
Abstract
Objective The hapten of metronidazole was synthesized by using metronidazole and succinic anhydride in silicon carbide (SiC ) reactor assisting with microwave. Methods The hapten of metronidazole was prepared by using silicon carbide (SiC) or quartz glass (Pyrex) reactor by microwave radiation for 5 min at 120 ℃, and the product was also characterized. Results Hapten of metronidazole was prepared successfully by microwave-assisted irradiation by using SiC vial or Pyrex vial in high yield. Moreover, higher yield and better repeatability was obtained with SiC vial . Conclusion The results showed it' s a better choose to obtain hapten of metronidazole by microwave-assisted synthesis in SiC reactor.关键词
甲硝唑半抗原/微波/有机合成/非热效应Key words
hapten of metronidazole/microwave/organic synthesis/non-thermal effect分类
医药卫生引用本文复制引用
王淇,王成蹊,孙福强,贺丽敏,吴琼,梁炳焕,邱永彬,梅文杰..碳化硅管中微波辅助制备甲硝唑半抗原[J].广东药学院学报,2012,28(1):17-20,4.基金项目
广东省科技厅计划项目(2007B031513004) （2007B031513004）
广东药学院中青年骨干教师培养基金资助 （）
