中国妇幼健康研究2012，Vol.23Issue(3)：277-279,299,4.DOI:10.3969/j.issn.1673-5293.2012.03.010
大蒜素对IgA肾病模型大鼠Th1/Th2免疫平衡的影响
Effect of diallyl trisulfide on Th1/Th2 immune balance in rats with IgA nephropathy
摘要
Abstract
Objective To explore the influence of Thl/Th2 immune balance on pathogenesis of IgA nephropathy ( IgAN ) and the effect of diallyl trisulfide ( DATS ) on rats with IgAN. Methods Thirty female SD rats were randomly divided into 5 groups: normal control group, IgAN model group, high-dose DATS group, low-dose DATS group and prednisone group. After 8 weeks of treatment, the kidneys were observed for morphological changes, and the contents of serum IL-4 and IFN-γ were detected by ELISA. Results Compared with model group, the high-dose and low-dose DATS groups had obviously lower level of serum IL-4 ( P = 0. 0001, both P <0.01 ), but there was no significant difference between two groups ( P > 0. 05 ). The difference of IL-4 in prednisone group and model group was not statistically significant ( P =0. 071 > 0. 05 ). The level of serum IFN-γ in high-dose and low-dose DATS groups was significantly higher than that of model group ( Phigh-dose= 0. 016, Plow-dise = 0.022, both P < 0. 05 ), but there was not considerable difference between them ( P > 0.05 ). The IFN-γ level of prednisone group did not elevate significantly ( P = 0. 563 > 0. 05 ). Compared with model group, subepithelial IgA complex deposition and the pathological changes of renal tissue in high-dose and low-dose DATS groups were obviously reduced. Conclusion DATS can reduce the serum IL-4 level and raise serum IFN-γ in rats with IgAN, and therefore regulates Thl/Th2 cell balance disorders, reduces mesangial deposits of IgA immune complex and pathological changes of kidney. In this way DATS plays an important therapeutic and prognostic role in IgAN.关键词
IgA肾病/大蒜素/白细胞介素-4/干扰素-γKey words
IgA nephropathy ( IgAN )/diallyl trisulfide ( DATS )/IL-4/IFN-γ分类
医药卫生引用本文复制引用
赵文静,黄燕萍,孙艳,刘丽..大蒜素对IgA肾病模型大鼠Th1/Th2免疫平衡的影响[J].中国妇幼健康研究,2012,23(3):277-279,299,4.基金项目
陕西省科学技术研究发展计划资助项目(2008k14-02) （2008k14-02）
