中国妇幼健康研究2012，Vol.23Issue(3)：326-327,333,3.DOI:10.3969/j.issn.1673-5293.2012.03.027
降钙素原和hs-CRP在新生儿败血症诊断中的价值
Diagnostic value of procalcitonin and high sensitivity C-reactive protein in neonatal septicemia
李思袖 1刘小乖 1于淑群 1赵玉娟 1马海欣1
作者信息
- 1. 西安市儿童医院新生儿科,陕西,西安,710003
- 折叠
摘要
Abstract
Objective To explore the value of procalcitonin ( PCT ) and high sensitivity C-reactive protein ( hs-CRP ) in early diagnosis of neonatal septicemia. Methods The level of serum PCT was detected by semi-quantitative solid-phase immune chromatography and the level of serum hs-CRP was determined by immune turbidimetry at admission and recovery stage, and blood was cultured before antibiotic treatment in 146 neonates with septicemia, respectively. The blood samples were collected only once for the determination of PCT and hs-CRP in 113 non infection neonates. Results The levels of serum PCT ( 0. 36 ± 0. 08ng/mL vs 15. 19 ± 12. 87ng/mL, H = 13. 338, P < 0.01 ) and serum hs-CRP (3.3 ±1. 2mg/L vs 23. 2 ± 4. 7mg/L, H = 10. 271, P < 0. 01 ) were significantly higher in neonates with septicemia than those in non infection neonates. However, the levels of PCT and hs-CRP in septic neonates decreased significantly in recovery stage. If PCT≥0. 5ng/mL and hs-CRP≥3mg/L were used as the positive criterion, the sensitivities would be 94. 6% and 71. 5% , and the specificities be 85. 2% and 63. 9% for PCT and hs-CRP, respectively. Conclusion PCT and hs-CRP can be markers for early diagnosis of neonatal septicemia. The superiority of PCT is more apparent compared with hs-CRP, especially for the diagnosis of neonates with severe infections such as sepsis.关键词
新生儿/降钙素原/超敏C-反应蛋白/败血症Key words
newborn/procalcitionin ( PCT )/high sensitivity C-reactive protein ( hs-CRP )/ septicemia分类
医药卫生引用本文复制引用
李思袖,刘小乖,于淑群,赵玉娟,马海欣..降钙素原和hs-CRP在新生儿败血症诊断中的价值[J].中国妇幼健康研究,2012,23(3):326-327,333,3.
