中国妇幼健康研究2012，Vol.23Issue(3)：352-354,3.DOI:10.3969/j.issn.1673-5293.2012.03.037
秦巴山区HCMV先天性感染更昔洛韦治疗效果探讨
Discussion on efficacy of GCV on HCMV congenital infection in Qinba mountain area
摘要
Abstract
Objective To explore the influence of human cytomegalovirus ( HCMV ) intrauterine transmission on neonates and the efficacy of ganciclovir ( GCV ) on symptomatic infants in Qinba mountain area. Methods HCMV-IgM in serum was screened in pregnant women and their babies by ELISA, and HCMV-DNA in serum of infants was detected with PCR method 2 weeks after delivery. The clinical and experimental data of infants was collected. The symptomatic infants were treated with GCV for two weeks and followed up. Results The intrauterine transmission rate of HCMC was 36.49%( 27/74 )in Qinba mountain area, and HCMV active infection in pregnant was closely related to HCMV congenital infection of infants (χ2 = 17. 58, P <0. 001 ). HCMV congenital infection would impair every system and organ of infants. Through management with GCV for 2 weeks to symptomatic infants, 64. 29%( 9/14 ) HCMV became negative, and the hepatic function indexes such as TBIL, DBIL, ALT and GGT dropped significantly. Conclusion HCMV congenital infection is serious to infants, and GCV is effective in treating symptomatic infants.关键词
人巨细胞病毒/先天性感染/活动性感染/更昔洛韦Key words
human cytomegalovirus ( HCMV )/ congenital infection/ active infection/ ganciclovir ( GCV )分类
医药卫生引用本文复制引用
李琦,李芬..秦巴山区HCMV先天性感染更昔洛韦治疗效果探讨[J].中国妇幼健康研究,2012,23(3):352-354,3.基金项目
国家自然科学基金资助项目(30170981) （30170981）
